A key component of the Strategic Research Initiative is investing in the latest resources and tools that can benefit biomedical researchers across campus and beyond. Click on the components of the Resource Center, below, to learn more.

In Silico Protein Analysis Module

The In silico protein analysis module, directed by Dr. Santiago Schnell (schnells@umich.edu), helps PFD investigators make predictions about protein structure, analyze proteome data and model biochemical pathways related to the causes, control and prevention of PFDs.

The module provides four types of services:

Reaction Kinetics is widely applied to study reaction mechanisms and their engineering at the molecular level.  The mechanistic information is valuable in the context of the development of therapeutic strategies to combat diseases.

Mathematical and Computational Modeling is used to formulate several hypothetical model mechanisms in parallel, which are compared with independent experimental data.  The resulting comparisons satisfying statistical measures of similarity will be used to make new experimental predictions, which can be tested experimentally.

Bioinformatics tools can be used to predict systemic features of proteins with the aim of understanding the determinants modulating protein aggregation and making qualitative predictions of protein structure.

Proteomic Analysis Service assists with the analysis of mass spectrometry-based proteomics data generated in the Pathology Proteomics Resource facility.

For more information or access to the services of this module:

Complete this form

PFD Reagent Library

PFD reagent library facilitates research by sharing critical reagents: plasmids, validated antibodies and protein quality control reporter vectors relevant to PFD studies. Antibodies – The catalog contains validated antibodies which have been complied from various PFDI investigators for the purpose of lowering the barriers to explore new ideas in research.  Antibodies are available to any PFDI members laboratory. Each PFDI member can receive a maximum of one aliquot per each antibody listed in the catalog. To view the list of antibodies, click on the catalog.  If you have questions on the antibody, please contact the investigator.  For other questions, contact Matthew Perkins at perkmd@umich.edu.

Human Disease Brain Bank

Human disease brain bank facilitates analysis of human disease tissue by PFD investigators.

  • The brain bank contains frozen and fixed brain tissue from several hundred individuals with age-dependent neurodegenerative PFDs or similarly aged, cognitively normal controls. Most cases are linked to detailed clinical information, which is stored and disseminated in a manner that ensures patient confidentiality.
  • Access to tissue and clinical information will occur by request through the brain bank web portal. We anticipate that the PFD human tissue bank will expand to bank additional organs relevant to PFDs as the PFD initiative grows.

Please contact Matthew Perkins with any questions, perkmd@umich.edu

Mouse Model Library

The mouse model library holds a compendium of model systems that are available across campus.  The list includes models of specific diseases, mutants of components of the protein quality control machinery, sensors of proteostasis, or other models that are of interest to the PFD community.  We believe the availability of this resource will facilitate new collaborations and speed scientific discovery.   If you are interested in sharing your model/s: Complete this form For the current list of mouse models, click here.