Many devastating human diseases arise from the accumulation of unfolded and aggregated proteins including amyotrophic lateral sclerosis (ALS), AD, HD and PD. How unfolded proteins, either as soluble or aggregated species, cause disease remains poorly understood, and multiple mechanisms are likely involved.
Existing therapeutic strategies include dissolving already-formed oligomers or aggregates and preventing protein aggregation by enhancing early steps of protein folding or degradation. Here we propose new strategies based on the hypothesis that up-regulation of vesicular trafficking pathways, lysosomal function and/or autophagy can clear cells of toxic proteins.
We will take advantage of our extensive, complementary expertise in the molecular mechanisms of membrane transport to develop these novel approaches to therapy.
All meetings begin at 3:00 pm and are open to only faculty associated with the hub
February 14, 2020 – Ming Li – 4243 LSI
March 13, 2020 – Mara Duncan – To be held via BlueJeans
April 17, 2020 – Haoxing Xu – To be held via BlueJeans
May 8, 2020 – Dan Klionsky – 3405 LSI
June 12, 2020 – Yanzhuang Wang – 6243 LSI
July 10, 2020 – Sami Barmada – 6243 LSI
August 14, 2020 – Cathy Collins – 3405 LSI
September 11, 2020 – Lois Weisman – 6243 LSI
October 9, 2020 – Phyllis Hanson – 3405 LSI
November 13, 2020 – Ming Li – 6243 LSI
December 11, 2020 –
Lois S. Weisman
Lois S. Weisman is the Sarah Winans Newman Professor of Cell and Developmental Biology and Research Professor in the Life Sciences Institute. Studies in her lab focus on baker’s yeast. The hope is that understanding how a single-celled organism functions will likely provide key insights into control of more complicated cells such as neurons, and will ultimately provide new information about animal physiology.
Daniel J. Klionsky
Daniel J. Klionsky is the Alexander G. Ruthven Professor of Life Sciences. His laboratory uses yeast to study basic cellular processes including autophagy and organelle biogenesis.
Sami Barmada is the Angela Dobson and Lyndon Welch Research Professor of Neurology and an assistant professor of neurology. His laboratory investigates RNA and protein metabolism in primary neurons and human stem cell-derived neurons, how deficiencies in these pathways lead to neurodegeneration in ALS and FTD, and how these pathways can be modified to prevent neuron loss.
Mara Duncan is an Assistant Professor in the Department of Cell and Developmental Biology. Her laboratory uses cellular models to study the fundamental mechanisms and identify new genes important for destroying proteins that may contribute to neurodegeneration.
Yanzhuang Wang is a Professor of the Department of Molecular, Cellular and Developmental Biology (MCDB) and Department of Neurology; he also serves as the Associate Chair for Research and Facilities of MCDB. His research focuses on the biogenesis, function, and defects of the Golgi in diseases such as Alzheimer’s disease and cancer.
Phyllis Hanson is the Minor J. Coon Collegiate Professor in the Department of Biological Chemistry. She is also the Chair of Biological Chemistry. Her research focuses on understanding how proteins interact to regulate the structure and organization of cell membranes both inside and outside the cell, and has implications for understanding a wide range of diseases including among others neurodegenerative disorders such as Alzheimer’s disease and the debilitating movement disorder, dystonia.
Catherine Collins is an Assistant Professor of the Department of Molecular, Cellular and Developmental Biology . Her research is interested in the cellular mechanisms that neurons use to alter synaptic structure in response to environmental and developmental cues. Of particular interest is the cell biology of signaling within axons, which connect neurons to distant parts of the brain and body.
Haoxing Xu is a professor in the Department of Molecular, Cellular and Developmental Biology. His laboratory is interested in understanding the physiological and pathological functions of Transient Receptor Potential (TRP) ion channels, lysosome ion channels, and Ca2+ signaling.