There has been a recent explosion in the number of identified disorders linked to protein misfolding in the endoplasmic reticulum (ER), resulting in ER entrapment of exportable proteins accompanied by the deterioration of cell and tissue function. We are exploring potential therapies including treatments designed to avoid ER protein folding overload, enhance endogenous ER chaperone activities, and promote ER-associated degradation of misfolded mutant proteins. It is intended that such therapies will limit cell stress and cell death, and promote restoration of normal cell and tissue physiology.
All meetings are currently being held via Zoom
September 9, 2020 – Ling Qi Lab – Zoom Link
October 14, 2020 – Malini Raghavan Lab – Zoom Link
November 11, 2020 – Qing Li Lab – Zoom Link
December 9, 2020 – Les Satin Lab – Zoom Link
January 13, 2021 – Peter Arvan Lab – Zoom Link
February 10, 2021 – Billy Tsai Lab – Zoom Link
March 10, 2021 – Matthias Truttmann Lab – Zoom Link
April 14, 2021 – Andy Lieberman Lab – Zoom Link
May 12, 2021 – Amy Chang Lab – Zoom Link
June 9, 2021 – Ryan Baldridge Lab – Zoom Link
July 14, 2021 – Stephanie Moon Lab – Zoom Link
Peter Arvan is the William and Delores Brehm Professor of Diabetes Research, and Chief of the Division of Metabolism, Endocrinology & Diabetes (Depts. of Internal Medicine, and Molecular & Integrative Physiology). His laboratory uses cellular and mouse models to study protein folding and misfolding in pancreatic beta cells (proinsulin) and thyroid epithelial cells (thyroglobulin), in order to discover new treatments for conformational diseases that affect these cells of the endocrine system.
Billy Tsai is the Corydon Ford Collegiate Professor of Cell and Developmental Biology. His laboratory is interested in how pathogens exploit a cellular quality control pathway to cause infection.
Ling Qi is the Professor of Molecular & Integrative Physiology and Internal Medicine. His laboratory is broadly interested in the role of protein folding and degradation in endoplasmic reticulum and inflammation in human health and disease. They have recently generated new animal models recapitulating human obesity, type-1 diabetes and type-2 diabetes. Using cell biological, immunological and physiological tools, they strive to make discoveries and gain novel insights into the pathogenesis of human diseases.
Les Satin is a Professor of Pharmacology, and Affiliate Professor of Medicine (MEND division). His laboratory uses fluorescence calcium imaging methods, novel optical probes, patch clamp electrophysiology, and mathematical modeling to study the cellular and molecular basis of beta cell metabolic and secretory function and diabetes.
Malini Raghavan is Professor of Microbiology and Immunology and faculty member in the Immunology, Cellular and Molecular Biology and Biophysics graduate programs. Her laboratory studies human major histocompatibility complex (MHC) class I polymorphisms and their influences on protein folding and immunity, and the biology of endoplasmic reticulum (ER) chaperones.
Amy Chang is an Associate Professor in the Department of Molecular, Cellular & Developmental Biology. The Chang lab uses yeast as a model system to understand regulation of lipid homeostasis and the cellular consequences of lipid toxicity.
Stephanie Moon is Assistant Professor of Human Genetics and a Faculty Scholar of the Center for RNA Biomedicine. Her laboratory is interested in how genes are expressed via the coordinated regulation of messenger RNAs at the levels of translation, localization, and decay. They study mRNA regulation in the context of human disease and stress, with a particular interest in neurological disorders. Their research aims to reveal the underlying principles and mechanisms governing mRNA in both health and disease to elucidate new therapeutic and diagnostic strategies.
Andrew Lieberman is the Gerald Abrams Collegiate Professor of Pathology and Director of Neuropathology. His laboratory uses cellular and mouse models to study inherited forms of neurodegeneration in hopes of identifying targets for therapeutic intervention.
Ryan Baldridge is an Assistant Professor in Biological Chemistry. His laboratory is interested in the basic mechanisms of membrane-bound protein-quality control systems. We plan to determine how membrane-bound systems select substrates to identify cellular pathways regulated by these systems (including ERAD).
Brian Emmer is an Assistant Professor in Internal Medicine.