A Virtual Center

The first center of its kind connecting diverse expertise on disorders of abnormal protein accumulations and perturbations in “protein quality control”

Four Research Hubs

Our hubs investigate several of the most important research questions linking various PFDs. Each hub is comprised of basic and clinical-scientists and mines expertise across disciplines and diseases.

 

Targeting Chaperones

We study protein quality control across translational models of cancer, cardiovascular disease and neurodegeneration with the goal of defining mechanisms of protein homeostasis and identifying therapeutic targets. Our unified approach is based on the realization that a single cellular machinery, the Hsp90/Hsp70 based chaperone machinery, controls the activity.

Endoplasmic Reticulum

There has been a recent explosion in the number of identified disorders linked to protein misfolding in the endoplasmic reticulum (ER). We are exploring potential therapies including treatments designed to avoid ER protein folding overload, enhance endogenous ER chaperone activities, and promote ER-associated degradation of misfolded mutant proteins.

Protein Trafficking

Many devastating human diseases arise from the accumulation of unfolded and aggregated proteins including amyotrophic lateral sclerosis (ALS), AD, HD and PD. How unfolded proteins, either as soluble or aggregated species, cause disease remains poorly understood, and multiple mechanisms are likely involved.

Beyond Amyloid

Research in Hub 4 strives to go beyond the “beta amyloid hypothesis” of Alzheimer’s disease (AD) to address other factors contributing to AD and related forms of dementia. There are two major goals: 1) use interdisciplinary approaches to gain insight into disease mechanisms; 2) understand the relationship between altered metabolism and dementia symptom onset and disease severity.

Defining Protein Folding Diseases

At the root of many diseases is a cause hidden in molecules. It involves mutating protein molecules, which we refer to as protein misfolding. View this video to learn more about the Protein Folding Diseases Initiative at the University of Michigan.

News…

October 13, 2021 - Young Investigators Meeting

To view the recorded presentation, including Virginia Lee’s talk, please visit our Symposium page for the link.

October 14 - 8th Annual Symposium

This is our 8th Annual Symposium which will occur virtually from 12 noon and 3 pm.  Our keynote speaker is Martin Kampmann, Ph.D.  We will also have an internal presentation by Shyamal Mosalaganti, Ph.D. and talks from the top Young Investigators.  

See the Symposium tab for the registration link

PFD Seminar Series

Please join us on Thursday, November 4, at 3 pm via Zoom.  Ming Li, Ph.D., Assistant Professor in Molecular, Cellular and Developmental Biology will be presenting, “Mechanisms for Lysosome Membrane Regulation”  Please visit our Seminar Series page for the Zoom link.

Our team

Our team, comprised of more than 70 scientists and scholars from around the University, are exploring the basic mechanisms and consequences of misfolded proteins in human diseases.